GALVESTON — For the first time, researchers at the University of Texas Medical Branch, in collaboration with Tekmira Pharmaceuticals, have protected nonhuman primates against Marburg virus — Angola hemorrhagic fever.
The treatment was shown to be effective at a point when animals have detectable levels of the virus in their system and begin to show symptoms of the disease. The study appeared in the Aug. 20 edition of the journal Science Translational Medicine.
There are currently no vaccines or drugs approved for human use and no post-exposure treatment that has completely protected nonhuman primates against MARV-Angola, the most deadly Marburg viral strain, with a mortality rate of up to 90 percent.
This virus, which is in the same family as Ebola, has a rapid disease course — seven to nine days — in nonhuman primates. There have been two recent imported cases of MARV HF to Europe and the United States, further increasing concern regarding the public health threat posed by this deadly virus.
“The increasingly frequent outbreaks of filoviral HF in Africa evidenced by the current rapidly spreading outbreak in Guinea, Liberia and Sierra Leone illustrate the clear and present danger filoviruses represent to human health,” said UTMB’s Thomas Geisbert, professor of microbiology and immunology.
“As such, the development of effective countermeasures against these viruses is a critical need.”
Previous studies with nonhuman primates have examined countermeasures against MARV infection at times before the subjects showed any evidence of clinical illness.
The goal of this study, led by Geisbert and Ian MacLachlan, executive vice president and chief technical officer of Tekmira Pharmaceuticals, was to determine whether it is possible to protect animals against a lethal MARV-Angola infection when treatment was started at a point when animals have detectable levels of the virus in their systems and show the first clinical signs of disease.
Other authors of this paper include Chad Mire, Joan Geisbert, Krystle Agans, Daniel Deer and Karla Fenton from UTMB, and Emily Thi, Raul Ursic-Bedoya, Amy Lee and Marjorie Robbins from Tekmira Pharmaceuticals.
The research was supported by the U.S. Department of Health and Human Services and the National Institutes of Health.